Lexapro - an antidepressant - was duly approved by the FDA
in august 2002 after intense research and development. Lexapro
was a revolutionary drug to help fighting chronic depression
and anxiety disorder. Lexapro is highly recommended by the physicians
these days because of its effective usage. It is one of the
latest entrants in the category of SSRI Drugs that are non-addictive
unlike other antidepressants available in the market.
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The information here is supplied for the expertise of your
health care professional. We do not confirm the usage of this
drug as safe and appropriate. It is well recommended to seek
your doctors' advice before using this medicine.
Lexapro Withdrawal Symptoms
Lexapro withdrawal might become a difficult
process. Several symptoms may suddenly arise no sooner you
plan to withdraw Lexapro from your daily routine. Although
Lexapro withdrawals are not fatal, yet may it produce a lot
of discomfort and anxiety.
First of all when you are ready to quit Lexapro - get prepared
mentally to cope with the withdrawal symptoms. If possible take
a week or two off from office as it may hinder your work schedule.
Following are the symptoms of Lexapro withdrawal - commonly
» Memory and concentration problems
» Slurred - unclear speech
» Panic attacks (even if you never had one before)
» Mood swings like heightened irritability/anger
» Fear of losing your sanity
» Steady feeling of existing outside of reality
» Confused behavior
» Suicidal thoughts in some extreme cases
» Nausea or sick feeling
» Abdominal cramping, diarrhea
» Chills/ hot flashes
» Blurred or bluish vision
» Breaking out in tears
» An unconventional dizziness/vertigo
» The feeling of shocks, similar to mild electric one, running
through your body
» An unsteady walking
» Profuse sweating, especially at night
» Muscle aching and cramps
» Insomnia - sometimes extreme and very intense
» Hypersensitivity to motion, sounds, smells
» Loss of appetite
Mentioned above are some of the common and generally observed
withdrawal symptoms. If these symptoms are prolonged and becoming
a matter of concern - consult your doctor, as soon as possible.
occurs when a patients intake more than the required dosage of
Lexapro. Lexapro Overdose is very fatal and needs immediate medical
attention to avoid any casualty.
There certain symptoms by which you can detect Lexapro overdose.
When you find a patient breathing heavily under unconscious condition
chances are that he\she has overdosed Lexapro. A patient is generally
vomiting, looking drowsy and have a rapid heartbeat.
Whenever there is a case of Lexapro overdose - take immediate
action. Quickly call up a local poison control center. If you
cannot get through poison control center - contact emergency
room and ask them to send medic and ambulance. In the meantime
emergency help arrives try to trace a doctor in neighborhood
and provide medical attention to your ward. We always suggest
you to learn some tricks as a protective measure against overdose
Pregnancy and Lexapro
during pregnancy is not recommended by the doctors. Lexapro may
bring adverse effects to the unborn baby - though
this is not a surety. If you are planning to become pregnant
or already pregnant - we recommend you to talk to your doctor
and seek medical advice.
Clinical reports suggest that women consuming anti-depressant
(not all of them) during pregnancy - about 3-5% had some birth
defect. This may not be substantial but we guess that you would
not want to take any risk at all.
If you are planning to get pregnant - try quitting Lexapro beforehand
since it may become difficult later on. Moreover if you have
already given birth to a child - breast feeding is also not recommended.
Lexapro mixes with the breast-milk causing sedative feeling in
Lexapro and Alcohol
of alcohol and Lexapro can be very serious. Never ever consume
alcohol under the influence of Lexapro.
While you are undergoing the treatment of depression with Lexapro
avoid alcohol and alcoholic beverages. Doctors will give a strict
no-no to alcohol consumption if you are under Lexapro medication.
Make alcohol very occasional and limited - only if you cant escape
it. And never-ever pop Lexapro under the influence of alcohol - even
of Lexapro has to be very precise and followed under a certain
guideline. Below are some of the essential instructions - which
you must follow strictly to get the maximum effect of Lexapro:
» Talk to your doctor for the exact
amount of dosage that you require to take
Lexapro side effects
» Lexapro is an oral consumption medication
» Do not chew or crush Lexapro. Properly gulp it down
» Paxil may be taken with or without - in the morning
» Lexapro should be taken once every day
» Remember to fill prescriptions ahead of time to avoid
missing a dose
» Never double your dose to cover up. This may be fatal
» Follow exact timing schedule for Lexapro
» Keep your doctor informed on the progress of medication
Under general circumstances all the medicines have some sort
of side effects with them. Lexapro also have some sort of side
effects - ranging from mild to severe symptoms. Below are the
commonly reported side-effects of Lexapro:
» Dizziness or lightheadedness
» Skin rash, itching (hives)
» Fast talking and excited feelings - slurred speech
» Suicidal thoughts
» Agitation or restlessness
» Blurred vision
» Difficulty sleeping - Insomnia
» Dry mouth
» Frequent urination
» Increased or decreased appetite
» Increased sweating
» Sexual difficulties (decreased
sexual ability or desire, ejaculatory delay)
» Taste alterations
» Tremor (shaking)
» Weight changes
In case these side effects persist for a longer period - you
should contact your doctor immediately.
two researches were carried out on Escitalopram - the
active ingredient in Lexapro.
By: - Burke WJ. [ University of Nebraska Department
of Psychiatry, 985580 Nebraska Medical Center , Omaha , NE 68198
-5580, USA ]
The Research :
Escitalopram oxalate (S-citalopram, Lexapro),
a selective serotonin re-uptake inhibitor antidepressant which
is the S-enantiomer of citalopram, is in clinical development
worldwide for the treatment of depression and anxiety disorders.
Preclinical studies demonstrate that the therapeutic activity
of citalopram resides in the S-isomer and that Escitalopram binds
with high affinity to the human serotonin transporter. Conversely,
R-citalopram is approximately 30-fold less potent than Escitalopram
at this transporter. Escitalopram has linear pharmacokinetics,
so that plasma levels increase proportionately and predictably
with increased doses and its half-life of 27 - 32 h is consistent
with once-daily dosing. In addition, Escitalopram has negligible
effects on cytochrome P450 drug-metabolising enzymes in vitro,
suggesting a low potential for drug-drug interactions. The efficacy
of Escitalopram in patients with major depressive disorder has
been demonstrated in multiple short-term, placebo-controlled
clinical trials, three of which included citalopram as an active
control, as well as in a 36-week study evaluating efficacy in
the prevention of depression relapse. In these studies, Escitalopram
was shown to have robust efficacy in the treatment of depression
and associated symptoms of anxiety relative to placebo. Efficacy
has also been shown in treating generalized anxiety disorder,
panic disorder and social anxiety disorder. Results also suggest
that, at comparable doses, Escitalopram demonstrates clinically
relevant and statistically significant superiority to placebo
treatment earlier than citalopram. Analysis of the safety database
shows a low rate of discontinuation due to adverse events, and
there was no statistically significant difference between Escitalopram
10 mg/day and placebo in the proportion of patients who discontinued
treatment early because of adverse events. The most common adverse
events associated with Escitalopram which occurred at a rate
greater than placebo include nausea, insomnia, ejaculation disorder,
diarrhea, dry mouth and somnolence. Only nausea occurred in > 10%
of Escitalopram-treated patients.
Effects of Escitalopram on anxiety symptoms in depression
- Spadone C. [Hopital Saint-Louis (AP-HP) Paris , France ]
The Research :
Selective serotonin reuptake inhibitors,
the antidepressants most widely prescribed today, exert specific
action against various anxiety disorders and have an excellent
acceptability profile. In addition, anxiety problems are commonly
seen in depression, in the form of either characterized anxiety
disorders or associated anxious symptoms. Such symptoms of anxiety
result in increased risk of suicide and appear to be associated
with development of more severe and chronic depressive disorders.
Because of the adverse effects associated with anxiolytics, in
particular benzodiazepines, their indications have been restricted.
Consequently, first-line drug therapy for anxiety symptoms associated
with depression involves selection of an antidepressant having
anxiolytic properties. Specific serotonin reuptake inhibitors
are commonly favored at present since they have a less pronounced
sedative effect than the tricyclic antidepressants (e.g. amitriptyline,
maprotiline). Escitalopram, the active enantiomer of citalopram,
has demonstrated efficacy and rapidity of action upon depressive
symptoms seen in major depressive episodes. Global analysis of
three studies comparing citalopram and Escitalopram with a placebo
in depressive disorders allowed specific investigation of the
activity of these molecules upon the anxiety component of depressive
disorders. Anxiety was quantitatively evaluated using item 6
(inner tension) of the MADRS, and for two of the three studies,
using the anxiety sub-score of the HAM-D as well as the HAM-A
total score. The results for the two active molecules demonstrate
significant superiority in comparison with the placebo. Furthermore,
in the case of Escitalopram, this improvement appeared significant
as of the first week of treatment (p<0.05); by the end of
the second week of treatment, the degree of significance was
even more pronounced (p<0.001). The tolerability profile of
these two active substances was very good. These studies thus
demonstrate the efficacy of Escitalopram against anxiety symptoms
associated with depression, together with particularly interesting
rapidity of action. Use of an antidepressant with proven activity
against anxiety accompanying depression avoid the need for co-prescription
of tranquillizers, which themselves are not devoid of adverse
clinical trials and laboratory tests - Lexapro proved to
be very effective compared to its competitor antidepressants.
A study showed the result that Escitalopram - the main active
ingredient of Lexapro significantly reduce depression in children
and adolescents. A pooled analysis of flexible-dose studies demonstrating
that patients with major depressive disorder treated with either
escitalopram or CelexaTM (citalopram HBr) showed significantly
greater improvement than patients receiving placebo.
Moreover, Lexapro was significantly better tolerated than Effexor
XR, with four times as many patients in the Effexor XR group
discontinuing the study due to side effects. This is the first
study to demonstrate comparable remission rates between a selective
serotonin reuptake inhibitor (SSRI) and Effexor XR. The findings
were presented at a global meeting of neuro-psycho-pharmacologists
in Prague , Czech Republic .
Lexapro and Weight Gain
there is no cause for weight gain amongst Lexapro users. Lexapro
does not stimulate weight atleast under clinical condition.
Yet, there are cases of excessive weight gain during the consumption
of Lexapro. Several consumers of Lexapro complained that they
have gained too much weight within months while they were on
However it is not exactly known whether Lexapro results in weight
gain or weight loss. There are complaints of excessive weight
loss as well during Lexapro. Doctors believe that it's all concerned
with individuals eating habit and not by using Lexapro.
and insomnia are related only by one means. Insomnia is one of
the withdrawal symptoms of Lexapro. It is very much understandable
since the body takes some time to accumulate the withdrawn effects
Although you may hear the insomnia problem amongst the users - few
of them are correct information. Insomnia does not occur during
Lexapro consumption. Yet, users may find difficult to sleep when
they are withdrawn from Lexapro.
antidepressant Lexapro is one of the latest medicines in the
category of selective serotonin reuptake inhibitors (SSRIs) Drugs.
Lexapro medication depends on individual-to-individual as per
body intake. There are few advantages of Lexapro over its competitor
drugs - which can summarized as:
» In clinical trials, Lexapro 10 mg/day demonstrated comparable
efficacy to a higher dose of Celexa 40 mg/day.
What is Depression?
» Lexapro significantly improved depression for many patients
beginning at week 1 or 2 (full antidepressant effect may take
4 to 6 weeks).
» Lexapro effectively treats anxiety symptoms associated with
» At 10 mg/day, overall incidence of side effects and drop-out
rates due to adverse events were comparable to placebo.
» Simple 10 mg/day starting dose for all patients.
Depression in Men
Depression in Women
Symptoms of Depression
What is depression?
Have you been sad sometimes for some reason? Feeling
bogged down - after you have lost or departed from some loved
one. It often happens with every one of us. Life at that stage
looks meaningless and unworthy. This spell of bluesy feelings
- that brings a series of grief and disappointment is 'Depression.'
Depression may last for a long time - even perhaps years and
takes serious toll on your health.
Much like other physical ailments - depression also needs dour
medical attention. Depression can lead to severe illness. Amongst
the severe cases of depression - there are cases of suicide,
suicidal attempts, disability as well as prolonged illness. Patients
of depression suffer from alcohol abuse, lack of sleep, hostility,
impatience and restlessness.
Depression in men
Men of any age group - irrespective of age,
race, and economic group can suffer with depression. As men gets
older chances of depression grows subsequently. According to
an estimated 40% men suffers from some depression between the
ages of 40-60 years.
Men who are depressed sometimes disagree that they have problems
because they are taught to "be strong," and depression
may be misperceived as a weakness. Depression is not a weakness - at
all. It is a panic disease and it should not be left untreated.
Depression in women
Women are more prone to depression than men.
Infact depression amongst women is twice as much as of men. Studies
also reveal that over the course of a lifetime, nearly 1 in 4
women will experience a major depressive episode.
There are many speculations about depression in women. Reasons
could be any. It also been estimated that the greatest chance
of depression in women are during their childbearing years - usually
between 25-40 years. These are the times when women group has
to be very committed and demanded. Yet depression can catch you
any time. It may loss of love in young teenage years or unsatisfactory
Depression could be very fatal and requires immediate treatment.
Symptoms of depression
Depression can be detected quite easily.
You can yourself detect - whether
you are suffering with depression or not. Below are some of the
symptoms of depression. If you are coping with more than one
of these symptoms then you are also a victim of depression and
needs medical help.
» Feelings of sadness, depressed
mood, and/or irritability
» Loss of interest or pleasure in activities, such as
hobbies or spending time with family/friends
» Changes in weight or appetite
» Changes in sleeping pattern-sleeping too much or not
being able to sleep at all
» Feelings of guilt,
hopelessness, or worthlessness
» Inabilities to concentrate, remember things, or make
» Constant fatigue or loss of energy
» Restlessness or decreased activity
» Recurrent thoughts of suicide or death
Depression is not something you should feel
guilty. It is something that occurs to you rather unwontedly.
People - especially men
feels guilty to discuss the matter of depression in them.
People suffering with depression should medical attention as
soon possible. There are little chances that depression can be
cured by itself. Several therapies are implemented before you
can actually come across with depression.
Foremost - you should be mentally ready about fighting depression.
You have to bend certain psychological factors and get ready
to tackle them. If you do not sought medical attention - depression
can take a massive toll on your health. These include mental
and moral breakdown, physical break down and suicide in extreme
Below are some of the direct results of depression:
» Abuse of drugs and/or alcohol
FAQ about LEXAPRO™ (escitalopram oxalate)
» Chronic health problems such as cancer, heart disease, or
» Separation or divorce
» Decreased sexual potency
» Occupational stress
What is LEXAPRO?
LEXAPRO is an antidepressant that is the newest member of the family of medications
known as selective serotonin reuptake inhibitors (SSRIs). LEXAPRO was developed
by isolating a part of the CELEXATM (citalopram HBr) molecule, known as an isomer.
As a result, LEXAPRO is able to provide effective and well-tolerated therapy
for depressed patients.
How does LEXAPRO improve depression?
LEXAPRO helps to restore the brain's chemical balance by increasing the available
supply of serotonin, a substance in the brain believed to influence mood.
will I start feeling better?
In clinical studies, many patients treated with LEXAPRO began to feel improvement
in their depression beginning in 1 or 2 weeks, although full antidepressant effect
may take 4 to 6 weeks. You should follow up with your healthcare provider and
report your progress.
Can I stop taking LEXAPRO once I feel better?
No. You should take your medication as long as your healthcare provider instructs,
even if you start feeling better, because otherwise your depression could return
or worsen. Your healthcare provider may ask you to keep taking LEXAPRO even if
you are feeling better, to help keep your depression from coming back.
side effects with LEXAPRO?
LEXAPRO is well tolerated by most people. The most commonly reported side effects
of LEXAPRO are nausea, insomnia, problems with ejaculation, drowsiness, increased
sweating, and fatigue. Most of the side effects experienced by patients taking
LEXAPRO are mild and go away with continued treatment, and usually do not cause
patients to stop taking LEXAPRO.
Does LEXAPRO cause weight gain?
People treated with LEXAPRO experienced no clinically important weight change
as a result of therapy. If you have concerns about any other side effects, you
should talk with your healthcare provider.
How and when should I take LEXAPRO?
LEXAPRO should be taken once every day. It may be taken with or without food,
in the morning or evening. Also remember to fill prescriptions ahead of time
to avoid missing a dose. To get the best results, it is important to follow all
of your healthcare provider's instructions about how and when you should take
Can I take LEXAPRO with other medications?
LEXAPRO can be taken with most other medications except another family of antidepressants
called monoamine oxidase inhibitors (MAOIs). LEXAPRO and MAOIs should not be
taken together or within 14 days of each other. Before you begin taking LEXAPRO,
make sure to tell your healthcare provider if you are taking any other medications,
including over-the-counter medications, herbal remedies, diet supplements, etc.
What else can I do for my depression in addition to taking LEXAPRO?
When taking LEXAPRO, be sure to keep follow-up appointments with your healthcare
provider. He or she needs to keep track of how you are doing as you make progress
toward recovery. Your healthcare provider may suggest that you see a mental health
therapist in addition to taking LEXAPRO. A therapist can provide valuable advice
on how to cope with the challenges of life and help you better understand your
depression. While your healthcare professional should be your main source of
support in depression treatment, talking with a close friend or family member
can sometimes be very helpful.
What if I have more questions about LEXAPRO?
Your healthcare provider or pharmacist will be able to answer any additional
questions you may have about LEXAPRO and your depression treatment.